Policies, technological advances, and a shift in the work we do have reduced acute occupational injuries over the last 100 years. Increased awareness over the last 50 years in chronic injuries has impacted occupations and economies globally. In the last 25 years there has been more awareness of the costs of social injuries including a loss of work-life balance, working from home, and diversity and inclusion issues. This course examines these evolutions, how to assess impacts, and opportunities for change associated with the dynamics of occupational health. Lectures, case studies, and exercises are integrated with the overall objective to teach various methodologic and analytic approaches to studying the relationship between occupational and environmental exposures and health outcomes in humans and animals.