The first portion of this course focuses on the basic concepts and principles of pathology by analyzing the inherent mechanisms that underlie all disease processes. Students develop an understanding of the processes of cellular injury and adaptation, inflammation and repair, neoplasia, hematology, and laboratory testing. This portion of the course focuses on the pathophysiologic, molecular and genetic alterations that underlie all disease processes, and examines their associated cellular, tissue, and systemic manifestations. The osteopathic principles that emphasize the importance of homeostatic balance and sequelae of its disruption are stressed. The remaining portion of this course introduces students to the study of disease through an organ systems approach.