The final course in the Patient Symptom Presentations series continues to mirror the clinical experience. Complex symptoms include weight loss from the infant to the adolescent, altered mental status, the noncompliant patient, abnormal chest and abdominal radiographs, scrotal swelling, delivering bad news, and fatigue. These difficult discussion topics conclude with “Putting it All Together,” utilizing students’ diagnostic questioning, learned recognition, and association skills with underlying compassion and empathy.